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Persistently elevated IgA antibodies to Mycoplasma pneumoniae in patients with internal carotid artery stenosis

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Author(s): Daxböck, Florian | Assadian, Afshin | Watkins-Riedel, Thomas | Assadian, Ojan

Journal: GMS Krankenhaushygiene Interdisziplinär
ISSN 1863-5245

Volume: 6;
Issue: 1;
Start page: Doc04;
Date: 2011;
Original page

Keywords: Mycoplasma pneumonia | IgA | atherosclerosis | stenosis | elevated antibodies | A. carotis interna

ABSTRACT
Background: It has been suggested that Mycoplasma pneumoniae may play a role in the development of atherosclerosis, but to date this association is still a matter of debate due to conflicting findings. Methods: We have investigated the levels of specific IgA antibodies to M. pneumoniae in 91 patients with internal carotid artery (ICA) stenosis using a commercial kit (SeroMP™ IgA; Savyon Diagnostics, Israel; cut-off value: 20 binding units; BU). All patients underwent surgery for ICA stenosis. From each patient, the first serum sample (S1) was taken before surgery, and the second after an interval of 6 month (S2). Results: The S1 seroprevalence was 18.7% (17/91). Thirteen of the 17 patients with positive S1 levels also remained positive after six month, whereby no decrease of IgA level was seen (median S1 level: 34 BU, range: 22–65 BU; median S2 level: 37 BU, range: 22–58 BU). Specifically, six of the patients showed an increased level after 6 months, and six a decrease, with the level remaining constant in one patient. In contrast, only 3 of the 74 S1 negative patients became positive for anti-M. pneumoniae IgA between the taking of the first and the second serum specimen (p
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