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A perspective study on elective single blastocyst transfer

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Author(s): Wei-zhou WANG | Ai-ming WANG | Wei SHANG | Min LI | Cheng-jun LIU | Di WU | Yong ZHAO | Yu-liang SHEN

Journal: Medical Journal of Chinese People's Liberation Army
ISSN 0577-7402

Volume: 37;
Issue: 9;
Start page: 719;
Date: 2012;
Original page

Keywords: embryo transfer | pregnancy | multiple | ovarian hyperstimulation syndrome

ABSTRACT
Objective To study the effect of elective single blastocyst transfer (eSBT) on the pregnancy outcome of women undergoing in vitro fertilization and embryo transplantation (IVF-ET). Methods A perspective study on eSBT was conducted from March 2007 to December 2011. The patients were divided into three groups based on embryonic development and number of embryos transplanted: group A, single blastocyst transfer (n=287); group B, two blastocysts transfer (n=53); group C, cleavage stage embryo transfer (n=382). The difference in clinical data, laboratory data and pregnancy outcome were compared among the three groups. Patients from group A and B who achieved to have at least two good blastocysts were reviewed, and divided into twice single blastocyst transfer (T-SBT) group and once two blastocysts transfer (O-DBT) group. With the cumulative transplantation of two blastocysts serving as an example, the pregnancy rate and cumulative pregnancy rate were compared between the T-SBT group and O-DBT group. Results The clinical pregnancy rate in single transplantation cycle decreased significantly in group A compared with that of group B (P < 0.05), and the multiple pregnancy rate declined obviously compared with group B (P < 0.01). No statistical difference was found between group A and group C on the clinical pregnancy rate (P>0.05), but the implantation rate was increased and multiple pregnancy rate was lower significantly in group A (P < 0.01). The incidence of ovarian hyperstimulation syndrome (OHSS) decreased significantly in group A compared with group B and group C (P < 0.01). The clinical pregnancy rate decreased significantly in once single blastocyst transfer group than in once two blastocysts transfer group (P < 0.05). However, no significant difference was found on the cumulative pregnancy rate between the twice single blastocyst transfer group and once two blastocysts transfer group (P>0.05). Conclusion Compared with two blastocysts transfer and cleavage stage embryo transfer, elective single blastocyst transfer may obviously decrease the multiple pregnancy rate and OHSS rate, therefore it is suitable to apply in some of patients who meet the criteria.

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