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Pharmacokinetics of Cefepime Following Intravenous and Intramuscular Administration in Sheep

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Author(s): P. N. Patel | U. D. Patel | Sh. K. Bhavsar | A. M. Thaker

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 9;
Issue: 1;
Start page: 7;
Date: 2010;
Original page

Keywords: Pharmacokinetics | Cefepime | Sheep | Intravenous | Intramuscular

ABSTRACT
Pharmacokinetics of cefepime was studied following single dose intravenous and intramuscular administration at the dose of 20 mg/kg of body weight in sheep. Drug concentration in serum was determined using high performance liquid chromatography (HPLC). Following single dose intravenous administration, the drug was rapidly distributed (t1/2a: 0.20 ± 0.02 h) and eliminated (t1/2b: 2.54 ± 0.12 h) from the body. The area under curve (AUC0-¥) was 135.50 ± 5.63 mg h/mL. The drug was cleared at the rate of 2.48 ± 0.09 mL/min/kg with mean residence time (MRT) of 2.84 ± 0.13 h. Following IM administration, the drug was rapidly absorbed (Cmax: 26.34 ± 1.44 mg/mL; tmax: 0.75 h) and slowly eliminated (t1/2b: 5.17 ± 0.44 h) from body. The volume of distribution at steady state (Vdss), area under curve (AUC), total body clearance (ClB) and mean residence time (MRT) were 1.11 ± 0.10 L/kg, 140.90 ± 8.67 mg h/mL, 0.15 ± 0.01 mL/min/kg and 6.89 ± 1.0 h, respectively. The bioavailability of cefepime following intramuscular administration was 103 ± 8.0 %.

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