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Pharmacological Characterization of the Rat Paw Edema Induced by <i style=`mso-bidi-font-style: normal`>Echis pyramidum Venom

Author(s): Abdulrahman Khazim Al Asmari

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 3;
Issue: 9;
Start page: 824;
Date: 2003;
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Keywords: Rat paw edema | echis pyramidum venom (EqV) | inflammatory mediators | antagonist | antivenom

The present study was conducted to investigate the inflammatory response induced by Echis pyramidum venom (EpV) in the rat hind-paw by measuring paw edema. Non-heated EpV (3.125-50 µg paw-1) caused a marked paw edema (plateau) accompanied by intense haemorrhage(not shown); whereas heated venom (97°C, 30 s; 3.125-50 µg paw-1) produced a dose and time-dependent non-haemorrhagic edema. The response with heated EpV was maximal within 15 min, disappearing over 24 h. Heated EpV (25 µg paw-1) was optimized to test the effect of various drugs on edema induced by the EpV. The results showed that dexamethasone, H1 and H3 receptor antagonist cyproheptadine and H1 receptor antagonist chlorpheniramine markedly (P
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