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Pharmacological evaluation of anti-tussive, anti-asthmatic and expectorant activities of Calotropis gigantea R.Br. in experimental animals.

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Author(s): Jaliwala Y.A.*1,Chourasia Neha1, Bhatt N. K. 1, Panda P.K.2 , Mohanti P.K.1

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3383;
Date: 2011;
Original page

Keywords: Calotropis gigantea (c. gigantea) | Antitussive | Anti-asthmatic | Expectorant | coughing | ethanolic extract (EEC) | aqueous extract (AEC).

ABSTRACT
The whole flower extract of the Calotropis gigantea, R.Br. was subjected to Pharmacological evaluation of Anti-tussive, Anti-asthmatic andExpectorant activities Materials and Methods:Albino Wistar rats, guinea pigs and mice were the experimental animals for different test. Respiratory symptomlike anti-tussive activity determined by inducing cough through ammonia, sulfur dioxide, citric acid induced for three activity respectively in mice andantiasthmatic (determined in guinea pigs) and expectorant activity ( determined by Expectorant test) were carried out, following the oral administration of wholeflower extract of Calotropis gigantea, R.Br at the dose level of 250mg/kg and 500mg/kg. Results:The antitussive and antiasthmatic activities of aqueous extractsof C.gigantea were significant (P < 0.001). The maximum antitussive and antiasthmatic effect was observed a at the dose of 500 mg/kg and was comparable to thatof 250mg/kg it show dose dependent effect. The expectorant test show that the ethanol extract more effective than other extract of C.gigantea were significant(P < 0.001) observed at dose of 250mg/kg. Conclusion:Aqueous extract of Calotropis gigantea has shown significant antitussive effect and anti-asthmaticactivities at the dose of 250mg/kg and 500mg/kg was comparable with corresponding standard drugs. The ethanol extract show significant expectorant activitythen other extract of C.gigantea. The activity was attributed to the presence of phytoconstituents in the tested extract.
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