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Pharmacological evaluation of Jatropha curcas L. extract for Anti-diarrhoeal Activity

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Author(s): Kamal Sachdeva | Preeti Garg | Manmohan Singhal | Birendra Srivastava

Journal: Research in Pharmacy
ISSN 2231-539X

Volume: 2;
Issue: 2;
Start page: 1;
Date: 2012;
Original page

Keywords: Castor oil-induced diarrhoea | charcoal meal transit test | diarrhoeal | Jatropha curcas | magnesium sulphate induced diarrhoea

ABSTRACT
The present study provides the pharmacological evaluation of stem bark extract ofJatropha curcas L. for anti-diarrhoeal activity in rats. We made an attempt to study theeffect of stem bark extract of Jatropha curcas L. on diarrhoeal disease. The differentactivities studied were castor oil-induced diarrhoea, magnesium sulphate induceddiarrhoea and charcoal meal transit test. The result of the study reflected that methanolextract of the stem bark (100, 300 mg/kg) decreased total no. of faeces, wet faeces anddistance travelled by charcoal plug and showed the anti-diarrhoeal activity. Jatrophacurcas L. extract demonstrates the anti-diarrhoeal activity in rats.

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