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PHARMACOLOGICAL SCREENING OF MUSA PARADISICA LINN AGAINST ETHYLENE GLYCOL INDUCED RENAL CALCULI

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Author(s): Jha U | Shelke TT | Oswal RJ | Adkar PP | Navgire VN

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 3;
Start page: 995;
Date: 2011;
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Keywords: Renal calculi | Musa paradisica Linn | Ethylene Glycol | Calcium Oxalate Crystals.

ABSTRACT
The effect of ethanol extract of dried roots of Musa paradisica Linn against ethylene glycol induced renal calculi in albino wistar rats are studied in this research. A renal calculus was induced in rats by ingesting 0.75% ethylene glycol in drinking water for 28 days and was manifested by high urinary calcium, oxalate, and low urinary magnesium contents. Simultaneous administration of 1ml (1 in 10) Musa paradisica Linn orally for 28 days along with ethylene glycol (0.75% v/v) reduced urinary calcium, oxalate and elevated urinary magnesium level. It also increased urinary volume thereby reducing the tendency for crystallization. The histopathological studies confirmed the induction as degenerated glomeruli, necrotic tubule and inflammatory cells was observed in section of kidney from animals treated with ethylene glycol. This was reduced; however after treatment with Musa paradisica Linn. These observations enable to conclude that Musa paradisica Linn is effective against ethylene glycol induced renal calculi.
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