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Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities

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Author(s): Cristiane B. de Oliveira | Lucimara N. Comunello | Adroaldo Lunardelli | Robson H. Amaral | Melissa G. S. Pires | Gabriela Lucas da Silva | Vanusa Manfredini | Carmen Regla Vargas | Simone C. B. Gnoatto | Jarbas R. de Oliveira | Grace Gosmann

Journal: Molecules
ISSN 1420-3049

Volume: 17;
Issue: 1;
Start page: 1113;
Date: 2012;
Original page

Keywords: anti-inflammatory | antioxidant | Baccharis trimera | phenolic compounds | pleurisy | saponin | TAR

ABSTRACT
Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) from B. trimera were evaluated. Using carrageenan-induced pleurisy as a model of acute inflammation, the phenolic extract at 15 mg/kg decreased significantly the analyzed parameters when compared to the carrageenan group ( p < 0.05), thus showing potential anti-inflammatory activity. The total phenolic content and antioxidant activity were evaluated by the Folin-Ciocalteau and DPPH methods, respectively. Phenolic and ethyl acetate extracts presented higher antioxidant activity ( p < 0.05) than ascorbic acid. The phenolic extract also showed the highest antioxidant potential in relation to the other extracts, thus suggesting that the antioxidant and anti-inflammatory activities were due to the presence of phenolic compounds.

Tango Jona
Tangokurs Rapperswil-Jona

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