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Phosphodiesterase-5 inhibitors use in patients with erectile dysfunction and cardiovascular disease in clinical practice

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Author(s): M.N. Mamedov | G.G. Sharvadze | E.A. Poddubsky | A.K. Ausheva

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 6;
Issue: 5;
Start page: 691;
Date: 2010;
Original page

Keywords: erectile dysfunction | cardiovascular disease | phosphodiesterase-5 inhibitors.

ABSTRACT
About 150 million men worldwide and about 50% of men aged 40-88 y.o. in outpatient practice suffer from erectile dysfunction (ED). There is a linear relation between the age and ED rate. The main reason of ED in the majority of men (about 80% of patients) is cardiovascular diseases (atherosclerosis, hypertension, diabetes mellitus), as well as certain risk factors (smoking, alcohol abuse, physical inactivity etc.). The problem of ED in cardiac outpatients and modern pharmacotherapy is discussed. The phosphodiesterase-5 (PDE5) inhibitors increase the relaxing effect of nitric oxide and increase cyclic GMP levels during sexual arousal. It results in increase of cavernosum blood flow, contributing to the physiological erection. Three PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are used in clinical practice nowadays.
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