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Phosphodiesterase 3 inhibition and cough in elderly asthmatics

Author(s): Ishiura Yoshihisa | Fujimura Masaki | Nobata Kouichi | Abo Miki | Oribe Takayoshi | Myou Shigeharu | Nakamura Hiroyuki

Journal: Cough
ISSN 1745-9974

Volume: 1;
Issue: 1;
Start page: 11;
Date: 2005;
Original page

Keywords: cough reflex sensitivity | capsaicin | cilostazol | phosphodiesterase | bronchial asthma

Abstract Aims Cough is a common symptom of bronchial asthma, a chronic inflammatory airway disease. Recently, the therapeutic effects of selective phosphodiesterase (PDE) inhibitors have been focused on bronchial asthma. This study was designed to investigate the clinical effect of PDE 3 inhibition on cough reflex sensitivity in elderly patients with bronchial asthma. Methods Effects of cilostazol, a PDE 3 inhibitor, on cough response to inhaled capsaicin were examined in 11 patients over 70 years with stable asthma in a randomized, placebo-controlled cross over study. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough reflex sensitivity. Results The cough threshold was significantly (p < 0.05) increased after two-week treatment with cilostazol (100 mg twice a day orally) compared with placebo [48.8 (GSEM 1.4) vs. 29.2 (GSEM 1.3) μM]. Conclusion These findings indicate that PDE 3 inhibition may be a novel therapeutic option for elderly patients with asthma, especially for their cough symptoms.

Tango Jona
Tangokurs Rapperswil-Jona

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