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Phosphoproteomics: Recent advances in analytical techniques

Author(s): Gomase VS | Ramu Akella

Journal: International Journal of Pharmaceuticals Analysis
ISSN 0975-3079

Volume: 1;
Issue: 2;
Start page: 31;
Date: 2009;
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Keywords: phosphorylation | enrichment | chemical modification | SILAC | mass spectrometry | HILIC

Post-genomic biology seeks identification and quantification of multiple proteins from complexmixtures and the research is still on. Despite recent progress in high-throughput proteomics, proteomicanalysis of post-translationally modified [PTM] proteins remains particularly challenging. Several strategiesfor isolating phosphoproteins are explored herein. Quantification of phosphoproteins seems to be a novelsolution to identify the underlying disease mechanisms, mostly cancer.
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