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Photobactericides—A Local Option against Multi-Drug Resistant Bacteria

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Author(s): Mark Wainwright | Leonard Amaral

Journal: Antibiotics
ISSN 2079-6382

Volume: 2;
Issue: 2;
Start page: 182;
Date: 2013;
Original page

Keywords: photobactericide | conventional resistance mechanisms | methylene blue

ABSTRACT
The use of light-activated bactericidal agents—photobactericides—is suggested in local infection in order to conserve conventional antibacterials for more systemic disease. Local administration of a photobactericide such as methylene blue coupled with locally-targeted red light illumination ensures the production of non-specific reactive oxygen species and thus a rapid and localised antibacterial response, regardless of the conventional resistance status. To this end, the response of photobactericides to conventional resistance mechanisms, and their potential use in infection, is discussed.
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