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Phytochemical, acute toxicity and anti-inflammatory studies on aqueous extract of Hallea rubrostipulata stem bark

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Author(s): Abayomi M Ajayi | W.O.Dunde | S.Abba | S.S. Dare | O.A.Okpanachi | J.K.Tanayen | J.O.C.Ezeonwumelu

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 03;
Issue: 04;
Start page: 203;
Date: 2012;
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Keywords: Aqueous extract | Acute toxicity | Carrageenan | Hallea rubrostipulata

ABSTRACT
The ethnomedicinal use of Hallea rubrostipulata stem bark as a remedy against malaria necessitated this study on its anti-inflammatory properties. The aqueous stem bark extract was subjected to phytochemical screening for the alkaloids, tannins, saponins, terpenes and flavonoids as secondary metabolites. Acute toxicity study of the aqueous extract showed that the extract was safe up to 2000mg/kg. The anti-inflammatory activity was examined using the carrageenan –induced oedema and formalin test in rats. The extract at doses (200, 400 and 800mg/kg) and indomethacin significantly (P

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