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PHYTOCHEMICAL ANALYSIS AND CARDIOPROTECTIVE ACTIVITY OF PLUMBAGO ZEYLANICA LINN IN ISOPROTERENOL PROVOKED OXIDATIVE MYOCARDIAL INJURY IN ALBINO WISTAR RATS

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Author(s): Karre siva venkata subhash | Tallapudi kiran kumar | N.Chidambranathan | Vinodth Prabhu

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 9;
Start page: 226;
Date: 2012;
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Keywords: Isoproterenol | Plumbago zeylanica | Cardiac biomarkers | Flavonoids | Myocardial infarction.

ABSTRACT
The phytochemical investigation of Plumbago zeylanica is done by using chemical tests and also by using analytical instruments like Fourier transform-Infra red spectroscopy and confirmed the presence of flavonoids. Isoproterenol a β- adrenergic agonist is used to induce the myocardial injury as it causes the generation of reactive oxygen free radicals and results in the necrosis of cardiac myocites. The Myocardial infarction is confirmed by serum analysis for Lipid profile, Cardiac biomarkers and the oxidative markers are also estimated in the tissue homogenate, the cardio protective effect of Plumbago zeylanica is confirmed by analysis of the above parameters and concluded that the hydro alcoholic extract of Plumbago zeylanica has the cardio protective effect.
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