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Phytochemical Characterization and in-vivo Anti-Malaria Activity of Lantana camara Leaf Extract

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Author(s): Gabi Baba | A.A.J. Adewumi | V.O. Aina

Journal: British Journal of Pharmacology and Toxicology
ISSN 2044-2459

Volume: 2;
Issue: 6;
Start page: 277;
Date: 2011;
Original page

Keywords: Anti-Malaria activity | FTIR spectral | Lantana camara | phytochemicals

ABSTRACT
The characteristic multi-drug resistant strains of Plasmodium to the existing anti-malaria has increase the global threat of malaria, couple with the wide medicinal application of Lantana camara in different countries and the literature of its use as anti-microbial, antifungal and insecticidal agents, and the quest for alternative anti-malaria this work look into the phytochemical screening, characterization and the In-vivo anti-malaria activity of the Lantana camara leaf extracts. The leaf extracts from plant were screened for phytochemicals and further FTIR characterized to correlate the routine qualitative phytochemical screening. In-vivo anti-plasmodia screening was carried out using 24 Swiss albino mice under laboratory conditions. The effectiveness of the aqueous and ethanolic extracts from the plant (L. camara) was compared with standard drug Chloroquine. The result indicated the presence of Alkaloids, Cardiac glycosides and Saponins in the Petroleum ether, aqueous and ethanolic extracts. Carbohydrate in both aqueous and ethanolic extracts, while Flavonoids and steroids in petroleum ether and ethanolic extracts. Tannins and terpenoids were present in aqueous and ethanolic extracts respectively. The identified phytochemicals correlate with FTIR spectral analysis from the identified characteristic functional groups. In-vivo study showed that Chloroquine was 83% effective in clearing the parasites, while aqueous and ethanolic extracts were 38 and 76% effective respectively. The curative capacity indicated possible concentration and time-dependency. The ethanolic extract showed higher level of anti-malaria potential and has indicated some level of protection.

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