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PHYTOCHEMICAL COMPOSITION, BIOACTIVITY AND WOUND HEALING POTENTIAL OF EUPHORBIA HETEROPHYLLA (Euphorbiaceae) LEAF EXTRACT

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Author(s): Omale James, | Emmanuel .T. Friday

Journal: International Journal of Pharmaceutical and Biological Research
ISSN 0976-285X

Volume: 1;
Issue: 2;
Start page: 54;
Date: 2010;
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Keywords: Euphorbia heterophylla | wound-healing activity | Phytochemical | bioactivity and Rattus novergicus

ABSTRACT
Villagers have traditionally used E.heterophylla parts to treat a variety of ailments. The objective of this study was to evaluate the phytoconstituents, bioactivity and wound healing potential of E.heterophylla leaf extracts in experimental Rattus novergicus.All experiments were conducted following standard procedures. The order ofdecreasing concentrations of the Phytochemical is alkaloids>cyanide >tannins>flavonoids> saponins. The order of decreasing cytotoxicity is aqueous extract (fresh)> ethanol extract (fresh)> ethanol extract (dry)> aqueous extract (dry). The extracts in the form of an ointment was used for evaluating the wound-healing potential in an excisionwound model. The wound-healing property observed in E.heterophylla is attributed to the phytoconstituents and the faster process of wound-healing could be a function of either the individual or additive effects of the phytoconstituents.The ethanol extracts exhibited high percentage of wound closure. The prophylactic effect elicited by the extracts in terms of wound contraction and related biochemical arameter strongly support the healing and sealing characteristics of E.heterophylla leaf gel in rats following topical administration.

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