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Phytochemical investigation & evaluation for antidiabetic activity of leafy extracts of various Ocimum (Tulsi) species by alloxan induced diabetic model

Author(s): Choudhury Golak Bihari*, Behera Manaswini, Panda Sangram Keshari and Tripathy Sujit Kumar

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 1;
Start page: 28;
Date: 2011;
Original page

Keywords: Ocimum | Lamiaceae | Antidiabetic | Alloxan induced diabetic model | glibenclamide.

The various species of Ocimum (Lamiaceae) i.e. Ocimum gratissimum linn., Ocimum americanum linn., Ocimum sanctum linn. and Ocimum basilicum linn. are widely distributed in tribal areas of south eastern Odisha and extensively used traditionally by the tribal people for common colds, headaches, stomach disorders,inflammation, heart diseases, antidiabetic, treatment of various forms of poisoning, malaria and as anthelmintic. The present study is an attempt to preliminary investigation of phytochemical constituents and to explore the antidiabetic activity of methanolic extracts of leaves of various Ocimum species including the comparison of their activity. The Ocimum extracts were screened for phytochemical constituents and evaluated for their antidiabetic activities by alloxan induced diabetic model in Wister rats. All the tests for phytochemical constituents of methanolic extract of Ocimum species were found to be positive except anthraquinone glycosides and thiol group. All extracts were able to show antidiabetic activity at 0.5 mg/Kg concentration. The activities are well comparable with the standard drug, glibenclamide. The methanolic extract of Ocimum sanctum linn showed better antidiabetic activity in comparison with other species of Ocimum and standard drug. The data were verified as statistically significant by using one way ANOVA at 5 % level of significance (p < 0.05).

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