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Phytochemical investigation and in vitro antioxidant evaluation of some Ocimum species

Author(s): Gayatri Nahak1, R.C Mishra2 and R.K. Sahu1*

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 7;
Start page: 2340;
Date: 2011;
Original page

Keywords: O. sanctum | O.basilicum | O.kilimandscharicum | O.gratissimum and Antioxidant activity.

Among the plants known for medicinal value, the plants of genus Ocimum belonging to family Lamiaceae are rich in phenolic compounds and are very useful for their therapeutic potentials. The various species of Ocimum (Lamiaceae) i.e. Ocimum gratissimum linn., Ocimum kilimandscharicum linn., Ocimum sanctum linn. and Ocimum basilicum linn. are widely distributed in tribal areas of south eastern Odisha and extensively used traditionally by the tribal people for commoncolds, headaches, stomach disorders, inflammation, heart diseases, antidiabetic, treatment of various forms of poisoning, malaria and as anthelmintic. In the present work an attempt has been made to compare the in vitro antioxidant activities of crude extracts of four Ocimum species namely O.sanctum, O.basilicum, O.kilimandscharicum and O.gratissimum using Water, Methanol and Ethanol as solvent by DPPH scavenging assay. In all the species, ethanolic extract gavemaximum yield of crude extract, phenol content as well as antioxidant activity. Highest antioxidant activity was demonstrated in O.sanctum (95.67%) followed by O.basilicum (89.54%), O.kilimandscharicum (77.53%) and O.gratissimum (68.87%). These values are comparable with Ascorbic acid as standard. Accordingly minimum IC50 values were obtained in the concentration of maximum antioxidant activity. These findings suggest that the rich phenol content of O.sanctum and its good antioxidant activity may be responsible for its popular and wide traditional use.
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