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Phytochemical screening and antibacterial properties of Hildegardia populifolia (ROXB.) Schott & Endl.

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Author(s): Sunilbabu Koppula1, K. Ammani1 and Varaprasad Bobbarala2*

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 3;
Start page: 907;
Date: 2011;
Original page

Keywords: Hildegardia populifolia | antibacterial | phytochemical properties.

ABSTRACT
Hildegardia populifolia (Roxb.) Schott & Endl. (Family-Sterculiaceae) commonly called Galli Budda is found in Tropical Dry Deciduous forests categorized under endangered species. It is also considered as one of the important traditional folk medicine. Hildegardia populifolia leaves are extracted with three solvents (Hexane, chloroform, methanol and aqueous extracts) were tested in vitro for their antibacterial activity. Leaf extracts of Hildegardia populifolia was investigated for antibacterial activity at 10 mg/ml concentrations by using Agar well technique method against human pathogens like Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginoasa, Bacillus subtilis, Staphylococcus aureus and Pseudomonas floresecneces. After incubation for 24 hrs, the zone of inhibition was compared with standard antibiotics streptomycin (10μg/ disc). From the dose dependent study it was observed that the methanol leaf extract was more potent than others solvent and aqueous extracts. Flavonoids and tannins present in methanolic extract may be responsible for the antimicrobial activity. Chloroform extract was effective against most of the microorganisms tested except P. aeruginosa and B. subtilis. Aqueous extract showed very low activity. Hexane extract was ineffective against all tested microorganisms.Phytochemical screening revealed the presence of flavonoids, tannins, steroids and saponins etc. The spectra of activities displayed by the extract and fractions can be attributed to the presence of these phytochemical which signifies the potential of Hildegardia populifolia (HP) as a source of therapeutic agents and may provide leads in the on going search for antimicrobial agent from plants. The overall results indicate promising baseline information for the potential uses of Hildegardia populifolia (HP) leaf extracts in treatment of infectious diseases.
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