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PHYTOCHEMICAL SCREENING AND DIURETIC ACTIVITY OF ALLIUM SATIVUM STEROIDAL AND TRITERPENOID SAPONIN FRACTION

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Author(s): Dr. Papiya Bigoniya et al

Journal: International Journal of Pharmaceutical Sciences and Research
ISSN 0975-8232

Volume: 3;
Issue: 9;
Start page: 3354;
Date: 2012;
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Keywords: Allium sativum | Steroidal saponin | Triterpenoidal saponin | Natriuretic | Aquaretic

ABSTRACT
Allium sativum L. (Liliacea) is a perennial bulb with a tall, erect flowering stem. The bulb of the plant has been used in many parts of the world as a stimulant, carminative, antiseptic, expectorant, anthelmintic and diuretic. This study has been planned to assess the diuretic activity of fresh garlic bulb extract targeting the steroidal and triterpenoidal saponin content. The rats were randomly divided into 4 groups of 5 animal each as vehicle control (2 % tragacanth suspension), standard drug frusemide (20 mg/kg, p.o), and n-butanol extract (10 mg/kg and 20 mg/kg, p.o) treated. Urine was collected in a graduated cylinder and its volume was measured for next 5 hr. Na+, K+ and Cl- concentrations were measured. Phytochemical analysis of A. sativum n-butanol fraction showed presence of steroids, triterpenoidal saponins and carbohydrates. At 20 mg/kg dose onset of diuresis and total volume of urine formed was significantly (P

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