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Pigmented Villonodular Synovitis

Author(s): Dr. Bhavuk Garg

Journal: Journal of Orthopaedics
ISSN 0972-978X

Volume: 2;
Issue: 4;
Date: 2005;
Original page

Keywords: Pigmented villonodular synovitis | Giant cells

Pigmented villonodular synovitis is an uncommon disease characterized by hyperplastic synovium, large effusions and bone erosions. The disease was first described by Jaffe et al. as a distinct entity in 1941.1 Pigmented villonodular synovitis (PVNS) is a locally aggressive benign tumor that arises from the synovial tissue. Another variant, giant cell tumor of tendon sheath is a similar synovial tumor that occurs in tendon sheaths. In the original description of the disease, the term "pigmented villonodular synovitis" was applied to a lesion that occurred in the synovial membrane of joints and tendon sheaths and was characterized by fibrous stroma, hemosiderin deposition, histiocytic infiltrate and giant cells.1 Subsequently, two forms of the disease were identified: a localized subtype characterized by a pedunculated lesion and a subtype with diffuse joint involvement.2
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