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Piperine and Quercetin Enhances Antioxidant and Hepatoprotective effect of Curcumin in Paracetamol Induced Oxidative Stress

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Author(s): Astha Mehta | Ginpreet Kaur | Meena Chintamaneni

Journal: International Journal of Pharmacology
ISSN 1811-7775

Volume: 8;
Issue: 2;
Start page: 101;
Date: 2012;
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Keywords: Antioxidant | quercetin | hepatoprotective | curcumin | piperine

ABSTRACT
Drug induced hepatotoxicity is a category of physiological oxidative stress caused by 50% drugs. Curcumin obtained from Curcuma longa is a potent antioxidant and hepatoprotective but has low bioavailability. Piperine and Quercetin were combined with Curcumin enhances oral bioavailability by inhibiting metabolic enzyme. The enhanced availability was hypothesized to potentiate hepatoprotective activity of curcumin by enhancing the antioxidant activity. The in vitro and ex-vivo antioxidant activity was measured by DPPH and TBARS method, respectively. The Albino Wistar rats used for in vivo method were pre-administered for 7days with Curcumin Combination consisting of Curcumin with Piperine and Quercetin (CPQ), Silymarin was used as reference drug. The animals were challenged with Paracetamol on 7th day to induce hepatotoxicity. Hepatoprotective activity was assessed by the levels of marker enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in plasma.The present findings of in vitro and ex vivo study showed statistical significance (p

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