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Pituitary ACTH cells in female rats after neonatal treatment with SRIH-14.

Author(s): Verica Milosević | Natasa Nestorović | Milica Terzić | Natasa Ristić | Vladimir Ajdzanović | Svetlana Trifunović | Milka Sekulić

Journal: Folia Histochemica et Cytobiologica
ISSN 0239-8508

Volume: 47;
Issue: 3;
Start page: 479;
Date: 2010;
Original page

The prolonged effects of neonatal SRIH-14 treatment on pituitary ACTH cells were investigated. Neonatal female rats were injected subcutaneously with SRIH (20 microg/100g b.w.) every 12 hours for five consecutive days (3rd-7th day of life). Groups of rats were then killed at the juvenile (16th day), peripubertal (38th day) or adult (80th day) stage. ACTH cells were visualized using the peroxidase-antiperoxidase immunocytochemical procedure. Morphometry and stereology were used to evaluate the ACTH-immunoreactive cell volume and volume density. The histological and immunocytochemical characteristics of ACTH cells in neonatally treated females were changed in all examined periods. Thus, SRIH-14 induced significant (p

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