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Plasma Cytokines and Trace Element Level in Severe Burn Rat Model-With Special Reference to Wound Healing Potential of Ampucare

Author(s): A. Soni | V.K. Dwivedi | M. Chaudhary | K. Malik | V. Naithani | S.M. Shrivastava

Journal: Research Journal of Immunology
ISSN 1994-7909

Volume: 3;
Issue: 1;
Start page: 22;
Date: 2010;
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Keywords: Zn and Cu | cytokines | burn wound healing | Ampucare

The present study was designed to determine the status of trace elements (Zn and Cu) and cytokines (IL-6, IL-1β and TNF-α) levels in severe burn rat model. Under brief anesthesia of ketamine, the shaved dorsum of the rats was exposed to 80°C (burn group) by hot wax for 5 min. The rats were fed standard pelleted diet and water ad libitum. The test room was air conditioned with temperature 23±2°C, humidity 65±5% and with artificial fluorescent light (10-14 h of light and dark), respectively. Rats were decapitated 24 h after burn injury and blood were taken for the determination of Zn, Cu and cytokines level. Present finding showed that level of Zn and Cu concentrations showed a significant trend of decrease in burned group and its levels were statistically increased (p
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