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Plasma Fatty Acid Composition in overweight or obese Hypertriglyceridemic Subjects with different FABP2 Genotypes

Author(s): H Pishva | S.A Mahboob | P Mehdipour | M Amini | M.R Eshraghian | S Hosainey | M Rahmany | K Abdy

Journal: Journal of School of Public Health and Institute of Public Health Research
ISSN 1735-7586

Volume: 6;
Issue: 3-4;
Start page: 27;
Date: 2008;
Original page

Keywords: FABP2 | PPARα | PCR-RFLP | Hypertriglyceridemia | Plasma Fatty acid composition

Background and Aim: The normal plasma fatty acid (FA) composition changes in hypertriglyceridemic obese and overweight indiuviduals. The objective of this study was to determine the plasma fatty acid composition in hypertriglyceridemic obese or overweight subjects with different FABP2 genotypes. "nMethods and Materials: Forty-six hypertriglyceridemic subjects (33 men and 13 women, 25-60 years old) referred to the Endocrinology and Metabolism Research Center (EMRC), Shariaty Hospital in Thehran, between Mehr and Esfand 1386 (September 2007-March 2008), were genotyped for FABP2 polymorphism by PCR-RFLP. In addition, their blood lipid profile was determind enzymetically, photometrically and immunoturbidometrically, and their plasma fatty acid composition by gas-choromatography. Also, body weights and heights were measured and body mass index calculated. "nResults: Positive associations were observed between Thr54 polymorphism in FABP2 protein and plasma lipid fractions (SFA, PUFA, ω-6-, ω-3- and total fatty acids (P
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