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Plasma Lipid Profile, Lipid Peroxidation and Antioxidant Status in Preeclamptic and Uncomplicated Pregnancies in Bangladesh

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Author(s): Md. Zakir H. Howlader | Yearul Kabir | Tanzir A. Khan | Md. Rakibul Islam | Firoza Begum | Fatma G. Huffman

Journal: Journal of Medical Sciences
ISSN 1682-4474

Volume: 7;
Issue: 8;
Start page: 1276;
Date: 2007;
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Keywords: Preeclampsia | lipid profile | total antioxidant status | thiobarbituric acid reactive substances | lipid hydroperoxides

ABSTRACT
To investigate the changes in plasma lipid profile, lipid peroxidation and antioxidant status in Bangladeshi pregnant women and their potential involvement in the pathophysiology of preeclampsia, we performed a case-control study consisting of randomly selected women (20-30 years) with preeclampsia (PE, n = 25) as compared to uncomplicated normal pregnant (UP, n = 22) and nonpregnant (NC, n = 25) women. The study was conducted in the Clinical Biochemistry Laboratory of Dhaka University. Serum lipid profile, thiobarbituric acid reactive substances (TBARS), lipid hydroperoxide (LHP), Total Antioxidant Status (TAS) and vitamin C levels were measured using standard methods. Serum total cholesterol levels of PE and UP groups were significantly higher (p
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