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Polymixin-B hemoperfusion in a case intolerant to conventional antibiotic therapy

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Author(s): Gilnardo Novelli | Vincenzo Morabito | Giancarlo Ferretti | Simone Novelli | Franco Ruberto | Milena Pernice | Cristina Cristina Donfrancesco | Perluigi Benedetti Panici

Journal: Journal of Biomedical Science and Engineering
ISSN 1937-6871

Volume: 05;
Issue: 03;
Start page: 101;
Date: 2012;
Original page

Keywords: Sepsis | Endotoxin Activity | Antibiotics

ABSTRACT
In this study we document how it was possible to resolve the septic complications of abdominal surgery, subjecting a patient severely allergic to intravenous antibiotics. We performed the hemoperfusion with polymyxin-B columns (PMX-DHP), guiding the therapy by assaying endotoxin activity and evaluating the clinical status of the patient after each session of PMX-DHP. The stabilization of hemodynamic and inflammatory frameworks were immediately observed after the PMX-DHP. The patient could be safely discharged five days after the discontinuation of the therapy. Our findings confirms data already published in literature concerning the effectiveness of PMX-DHP.

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