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POLYSACCHARIDE GUM (KONDAGOGU GUM) MATRIX TABLETS FOR ORAL SUSTAINED DELIVERY OF METOPROLOL SUCCINATE

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Author(s): N. Srujana | Valluru Ravi | T.M Pramod Kumar | S.Vinay | N. Aswani

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 4;
Start page: 1218;
Date: 2011;
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Keywords: Kondagugu gum | metoprolol succinate | matrix tablets | sustained release.

ABSTRACT
The present study has been undertaken to develop a sustained-release tablet dosage form for metoprolol succinate using kondagugu gum as the rate-controlling polymer. The prepared tablets were coated will shellac as an enteric coat polymer and evaluated for tablet properties. In vitro release studies of prepared tablets were carried out for 2 hrs in pH 1.2 HCl buffer and 22 hrs in pH 6.8phosphate buffer. In addition, swelling, kinetics of drug release from the matrices and stability of the tablet formulations were also investigated. Mathematical analysis of the release kinetics showed that the nature of drug release from the matrix tablets has followed super case II transport. FTIR and DSC studies have shown that no chemical interaction occurred between the drug and polymers used. The optimized formulation (F4) showed negligible difference in release mechanism as well as release kinetics when stability study was done for three months at 40±20 C and 75±5% RH.
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