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Population pharmacokinetics and its role in clinical therapeutics

Author(s): Dheeraj Gopu, Sravanthi A, Mamtha T, Sravan P, Radhika B, Jagadeeshwar K

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3334;
Date: 2011;
Original page

Keywords: Population Pharamcokinetics (PK) | demographical variability | NONMEM | P-PHARM

Population pharamcokinetics is study of inter-individual variabilities among a population which affect the pharmacokinetics of the drug or dosage regimen. Thesevariabilities occur due to the demographical, patho-physiological, age, disease (renal or hepatic failure) and concomitant drug administration. Population PK usedin drug development studies to set a therapeutic dose for a population which will avoid adverse effects because due to the variance in body profile there may bechange in the therapeutic index. Sometime due to the metabolic enzyme polymorphism there will be changes on dosage regimen. By using population PK studieswe can evaluate covariates responsible for this variability in respective population and also perform therapeutic drug monitoring for a target population.Population PK can be done in sparse samples also on dense sample data. Data analysis can be done by using different approaches. Now a day’s computer algorithmslike NONMEM, P-PHARM and other well developed software are using for data analysis. Mainly this review focused on the approaches to population PK,application of population PK in drug development phases, different computational softwares used for the data analysis and examples of study conducted from thelast 7 years.
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