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Possible Alternatives to Reduce Antibiotic Resistance

Author(s): SO Ogbodo

Journal: Life Sciences and Medicine Research
ISSN 1948-7886

Volume: 2011;
Start page: LSMR-24;
Date: 2011;
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Keywords: Antibiotics | resistance | prevention | alternatives

From the early time of discovery of antibiotics, the problem of resistance by microorganisms has been there. This problem has always been temporarily solved by systematic or accidental discovery of new drugs, either of the same class but with different side chains from the existing one or of another class altogether, thus helping to switch from the first-line drug to second-line or even third-line drug. These second- and third-line drugs are usually more expensive and sometimes more toxic than the firstline drugs. However, in many cases, no sooner had this drug been introduced that resistance to it by one microorganism or the other is noticed. Hitherto, the practice of mass-producing already existing cum resisted drugs by many pharmaceutical industries with different brand names and, often lower concentrations of the active molecules, is worsening the situation. It seems that this scenario will continue ad infinitum if alternative strategy is not employed. We reasoned that alternative solution to this will be the use of non-antibiotics with antimicrobial activities, especially those employing competitive displacement or improvement in immune functions as their modes of action. We reviewed different options for this, using published journal articles, fact sheets, and unpublished and personal communications.
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