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The Possible Biochemical Mechanism of Action of Petroleum-Ether Extract of Calotropis procera Leaves (Asclepiadaceae) - A Potent Abortifacient in Gravid Dawley Rats

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Author(s): A.B. James | G.M. Saibu, O.A. Magbagbeola, A.K. Oloyo and B.A. Iwalokun

Journal: Asian Journal of Medical Sciences
ISSN 2040-8765

Volume: 3;
Issue: 2;
Start page: 61;
Date: 2011;
Original page

Keywords: Abortifacient | β-adrenergic receptor | Calotropis procera | cAMP | muscarinic receptor | Myosin Light Chain Kinase (MLCK) | Protein Kinase A (PKA) | uterine contraction

ABSTRACT
Calotropis procera (Asclepiadaceae) is one of the traditionally used antifertility plants in Nigeria. Previous studies have shown that this antifertility plant has abortifacient property but none of them has reported its possible biochemical mechanism of action. Organ bath experiments using cumulative doses of the extract on rat uterine rings in Dejalon’s solution aerated with 95% O2 + 5% CO2 produced an increase in tension (% response) with an EC50 value of 0.1064 mg/mL. Blocking muscarinic receptors with 35 μg/mL atropine caused the dose-response curve to slightly shift to the right (EC50 shift = 0.1064-0.1242), with a significant (p
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