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POTENTIAL ROLE OF REDOX SENSITIVE SERINE KINASE PATHWAYS IN THE PATHOGENESIS OF INSULIN RESISTANCE IN RHEUMATOID ARTHRITIS

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Author(s): R. Vinayagamoorthi | Zachariah Bobby | A. Thiruvaimozhi

Journal: International Journal of Biomedical and Advance Research
ISSN 2229-3809

Volume: 2;
Issue: 8;
Start page: 259;
Date: 2011;
Original page

Keywords: Insulin Resistance | Rheumatoid Arthritis | Oxidative stress | Redox Sensitive Kinases

ABSTRACT
Objectives: Insulin resistance and oxidative stress have been reported in rheumatoid arthritis (RA). However, the molecular basis of insulin resistance in RA is not clearly understood. Recent studies have documented the role of redox sensitive serine kinase pathways in insulin resistance. The aim of the study is to investigate insulin resistance, oxidative stress andlymphocyte redox sensitive - nuclear factor - kB (NF-kB), c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinase (p38MAPK) pathways in RA subjects.Methods: Twenty newly diagnosed RA patients and 20 healthy volunteers in the age group of 30-50 years were included in this study. Overnight fasting blood was collected from the subjects, red blood cells, lymphocytes and plasma were separated using Ficoll hypaque.Blood oxidative stress parameters, fasting glucose and insulin were estimated. Redox sensitive serine kinase pathways in lymphocytes also studied.Results: The fasting insulin and HOMA-IR were significantly (p
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