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Potential therapeutic effects of pigment epithelium-derived factor for treatment of diabetic retinopathy

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Author(s): Xiao Liu | Hui-Hui Chen | Li-Wei Zhang

Journal: International Journal of Ophthalmology
ISSN 2222-3959

Volume: 6;
Issue: 2;
Start page: 221;
Date: 2013;
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Keywords: diabetic retinopathy | pigment epithelium derived factor | molecular therapeutics | pleiotropic functions

ABSTRACT
Diabetic retinopathy (DR), a major micro-vascular complication of diabetes, has emerged as a leading cause of visual impairment and blindness among working adults in the worldwide. The pathobiology of DR involves multiple molecular pathways and is characterized chronic neurovascular degeneration. Current approaches to prevent or to treat DR are still far from satisfactory. Therefore, it is important to develop new therapeutic strategies for the prevention and treatment to DR. Pigment epithelium-derived factor (PEDF), a 50-kDa secreted glycoprotein, has been described as a multi-functional protein. Some emerging evidences indicate that PEDF are able to target multiple pathways exerting neurotropic, neuroprotective, anti-angiogenic, antivasopermeability, anti-inflammation, anti-thrombogenic and anti-oxidative effects in DR. In this review, we addressed the functions of PEDF in different pathways, which could lead to potential therapeutics on the treatment to DR.
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