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Potentiating effect of ferulic acid, a plant poyphenol on cisplatin in combination chemotherapy in dalton’s ascites lymphoma mice model

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Author(s): Giftson J Senapathy 1 and Umadevi P 2*

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 8;
Start page: 2814;
Date: 2011;
Original page

Keywords: Combination therapy | Dalton’s Lymphoma | Antioxidants | Cisplatin | Ferulic acid

ABSTRACT
Due to the molecular complexity of many diseases, combination therapy is becoming increasingly important for a better long-term prognosis and to decrease side effects. ‘Combination cancer chemotherapy’ for the treatment of cancer generally refers to the administration of two or more pharmacologically active agents. In the present study, the effects of ferulic acid (FA), a plant polyphenol in combination with Cisplatin (CDDP), a standard anticancer drug in Dalton’s lymphomabearing mice was summarized. From the results, we found that administration of FA in combination with CDDP significantly altered the body weight, ascitic fluid volume, hematological parameters, serum antioxidants (SOD, CAT, GPx, GSH) levels, lipid peroxidation (TBARS) levels, hepatic enzymes (AST, ALT) activities and lipid profile of Dalton’s lymphoma bearing mice towards normal when compared to CDDP alone treated mice. These findings support the possible potentiating effects of FA on CDDP in combination therapy.
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