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Power of three multitrait methods for QTL detection in crossbred populations

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Author(s): Gilbert Hélène | Le Roy Pascale

Journal: Genetics Selection Evolution
ISSN 0999-193X

Volume: 36;
Issue: 3;
Start page: 347;
Date: 2004;
Original page

Keywords: multitrait | QTL | sib families | simulations

ABSTRACT
Abstract The multitrait detections of QTL applied to a mixture of full- and half-sib families require specific strategies. Indeed, the number of parameters estimated by the multivariate methods is excessive compared with the size of the population. Thus, only multitrait methods based on a univariate analysis of a linear combination (LC) of the traits can be extensively performed. We compared three strategies to obtain the LC of the traits. Two linear transformations were performed on the overall population. The last one was performed within each half-sib family. Their powers were compared on simulated data depending on the frequency of the two QTL alleles in each of the grand parental populations of an intercross design. The transformations from the whole population did not lead to a large loss of power even though the frequency of the QTL alleles was similar in the two grand parental populations. In these cases, applying the within-sire family transformation improved the detection when the number of progeny per sire was greater than 100.

Tango Jona
Tangokurs Rapperswil-Jona

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