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PRE-CLINICAL INVESTIGATION OF ANTI-TUSSIVE ACTIVITY OF HIBISCUS ROSA-SINENSIS ON GUINEA PIG

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Author(s): Jani Karna P | Gandhi Parth M | Ganatra Tejas H | Desai Tusharbindu R | Tirgar Pravin R

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 9;
Start page: 271;
Date: 2012;
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Keywords: Anti-tussive | Cough | Codeine | Hibiscus rosa-sinensis | Citric acid.

ABSTRACT
Ayurveda suggests that decoction of leaves of Hibiscus rosa-sinensis could be beneficial to reduce cough. Codeine and other synthetic antitussive agents shows number of side-effects and thus to find better and safer alternate Hibiscus rosa-sinensis was evaluated for its antitussive activity.Dried powder of flower part of Hibiscus rosa-sinensis was extracted with methanol and the practical yield of methanolicextract was found to be 1% W/W.Anti-tussive effect of methanolic extract of Hibiscus rosa-sinensis was studied in Histamine chamber using citric acid (7.5%W/V) induced cough model, in which the methanolic extract of Hibiscus rosa-sinensis significantly decreased the number of coughing. From this we concluded that methanolic extract of Hibiscus rosa-sinensis possess antitussive activity.
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