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PREDICTION OF STRUCTURES OF BIOACTIVE PEPTIDES BY USING HOMOLOGY APPROACH

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Author(s): Shrikant Sharma | Raghvendar Singh | Shashank Rana

Journal: International Journal of Biomedical and Advance Research
ISSN 2229-3809

Volume: 2;
Issue: 12;
Start page: 478;
Date: 2012;
Original page

Keywords: Swiss Model | Homology | Template | Peptides

ABSTRACT
In silico study for prediction of structures of bioactive peptides by using homology approach and different bioinformatics tools as Basic Local Alignment Search Tool (BLAST) Swiss Model workspace repository and template were applied. The homology model comprises four main steps find out the homology model against query protein identification of structural template(s) alignment of target sequence and template structure(s) model building and model quality evaluation. The feasible structures of antimicrobial antithrombotic casein derived immunomodulatory and mineral binding peptides were designed. Antimicrobial peptide seq8 (NP_446175.1) was analyzed by using above stated methodology and found that 3E6U chain D showed homology with this sequence. Like this methodology was followed for all query bioactive peptide sequences.
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