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Preliminary Anti-diarrhoeal Activity of Hydromethanolic Extract of Aerial Part of Indigofera Pulchra.in Rodents

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Author(s): Mohammed Aliyu

Journal: Asian Journal of Medical Sciences
ISSN 2040-8765

Volume: 1;
Issue: 2;
Start page: 22;
Date: 2009;
Original page

Keywords: Indigofera Pulchra | antidiarrhoeal | castor oil | isolated tissue | hydromethanolic extracts

ABSTRACT
Indigofera pulchra is used as remedies for many ailments such as in the treatment of diabetes,prophylactic against snake-bites and as anti- inflammatory, but has not been investigated for its anti-diarrhoealactivity. This study was therefore aimed at investigating the hydromethanolic portion of Indigofera pulchraaerial part extract for antidiarrhoeal activity, using castor oil-induced diarrhoeal model in mice. The effect ofthese extract on perfused isolated rabbit ileum were also evaluated. The hydromethanolic extract produced adosed dependent relaxation of the rabbit ileum. The hydromethanolic leaf extract produced a dose dependentprotection against the castor oil-induced diarrhoeal with the highest protection (80%), obtained at 500mg/kgcomparable to that of loperamide (5mg/kg), the standard agent. The preliminary phytochemical analysisrevealed that the extract contained tannins steroids, alkaloids, saponnis and flavonoids. The acute toxicity testrevealed the median lethal dose (LD50) value for the extract is greater than 5000mg/kg. The result obtainedrevealed that the leaves possess pharmacological activity against diarrhoeal.
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