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Preliminary serological secretome analysis of Corynebacterium pseudotuberculosis

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Author(s): Núbia Seyffert | Luis G.C. Pacheco | Wanderson M. Silva | Thiago L.P. Castro | Agenor V. Santos | Anderson Santos | John A. McCulloch | Maira R. Rodrigues | Simone G. Santos | Luiz M. Farias | Maria A.R. Carvalho | Adriano M.C. Pimenta | Artur Silva | Roberto Meyer | Anderson Miyoshi | Vasco Azevedo

Journal: Journal of Integrated OMICS
ISSN 2182-0287

Volume: 1;
Issue: 2;
Start page: 193;
Date: 2011;
Original page

Keywords: C. pseudotuberculosis | Caseous lymphadenitis | Secretome

ABSTRACT
Caseous lymphadenitis (CLA) is a chronic disease affecting small ruminants that is caused by Corynebacterium pseudotuberculosis and is responsible for significant economic losses. Various C. pseudotuberculosis secreted proteins are known to react with sera from infected goats. Mapping of the secretome would help us understand the pathogenesis of CLA. We identified six immunoreactive secreted proteins of C. pseudotuberculosis by 2D-Western blotting, using sera from goats with CLA, and characterized them by mass spectrometry. This preliminary information will give support to future studies aimed at the development of efficient vaccines and diagnostic kits.
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