Academic Journals Database
Disseminating quality controlled scientific knowledge

Preliminary study of steep pulse irreversible electroporation technology in human large cell lung cancer cell lines L9981

ADD TO MY LIST
 
Author(s): Song Zuoqing | Pan Zhenhua | Xu Xiaohong | Wang Weiqiang | Zu Lingling | Wang Jing | Song Zhitao | Liu Hongyu | Li Zhigang | Li Chengxiang | Chen Jun | Yao Chenguo | Zhou Qinghua

Journal: Archives of Biological Sciences
ISSN 0354-4664

Volume: 65;
Issue: 3;
Start page: 1211;
Date: 2013;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: steep pulsed | irreversible electrical breakdown | large cell lung cancer

ABSTRACT
Our aim was to validate the effectiveness of steep pulse irreversible electroporation technology in human large cell lung cancer cells and to screen the optimal treatment of parameters for human large cell lung cancer cells. Three different sets of steep pulse therapy parameters were applied on the lung cancer cell line L9981. The cell line L9981 inhibition rate and proliferation capacity were detected by Vi-Cell vitality analysis and MTT. Steep pulsed irreversible electroporation technology for large cell lung cancer L9981 presents killing effects with various therapy parameters. The optimal treatment parameters are at a voltage amplitude of 2000V/cm, pulse width of 100μs, pulse frequency of 1 Hz, pulse number 10. With this group of parameters, steep pulse could have the best tumor cell-killing effects.
Save time & money - Smart Internet Solutions     

Tango Rapperswil
Tango Rapperswil