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Preparation of BIT-layered Double Hydroxide and the Study of Antifungal Properties

Author(s): ZHANG Yi-Xuan, LI Song-Mei, LIU Jian-Hua, YU Mei

Journal: Journal of Inorganic Materials
ISSN 1000-324X

Volume: 28;
Issue: 9;
Start page: 1025;
Date: 2013;
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Keywords: layered double hydroxides; BIT; sustained-release; anti-mildew duration

Mg-Al layered double hydroxides, loaded with 1,2-benzisothiazolin-3-ketone(Mg2Al-BIT LDH), were synthesized via coprecipitation method. The resulting compounds were characterized by X-ray diffraction, Fourier transform infrared spectroscope and scanning electron microscope. Drug release kinetics were studied in the medium with pH at 4.8 and 7.2. The results showed that BITwas successfully inserted into the LDH inter layers, with a drug loading rate of 44.35%.The release kinetics process was in line with the quasi-second-order equation. The results showed that the antifungal effects of BIT were worse than that of Mg2Al-BIT LDHs in the final phase of the mold test due to its consumption, dissolution and precipitation, suggesting Mg2Al-BIT LDHs nano-hybrid a better anti-mildew duration.
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