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Preparation of Cefradine÷Montmorillonite Intercalation Compound

Author(s): ZHAO Yan-Zhao, GUO Wen-Ji, WANG Lan

Journal: Journal of Inorganic Materials
ISSN 1000-324X

Volume: 27;
Issue: 6;
Start page: 655;
Date: 2012;
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Keywords: montmorillonite; cefradine; ion exchange; solution intercalation

The cefradine/montmorillonite compounds were prepared by pharmaceutical montmorillonite (MMT) and sodium―montmorillonite (Na―MMT) by the method of solution intercalation. The drug load was quantitatively measured by UV spectrophotometry. The structures of compounds were determined by X―Ray Diffraction (XRD) and Fourier transformed infrared (FT―IR) spectroscope. The results show that cefradine can be intercalated into MMT mainly due to ion exchange, which cannot intercalate into MMT by mechanically mixing. Pharmaceutical MMT shows better ion exchange property after sodium modification, which is easily intercalated. The basal spacing of pharmaceutical MMT changes little after intercalation in water, however, the basal spacing of Na―MMT and pharmaceutical MMT after sodium modification increase.
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