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Preparation, Characterization and Biological Evaluation of Schiff Base Transition Metal Complexes with Cephradine

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Author(s): I.H. Bukhari | M. Arif | J. Akbar | A.H. Khan

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 8;
Issue: 4;
Start page: 614;
Date: 2005;
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Keywords: Metal based drugs | Schiff base complexes | transition metal complexes | antibacterial | coordination compounds

ABSTRACT
Transition metals (Mn (II), Co (II), Ni (II), Cu (II) and Zn (II)), complexes of Schiff base derived from Cephradine and Salicylaldehyde were prepared and characterized by elemental analysis, conductance, magnetic moments and spectroscopic data. In these complexes an amino group available in the Cephradine was allowed to react with Salicylaldehyde to obtain Schiff base and which then subsequently reacted with Transition metals. Schiff base was derived from condensation of salicylaldehyde and cephradine in equimolar quantities (1:1). Ligand chelates through OH and -C=N- functional group of the Schiff base. The complexes were formulated as ML2 (1:2) type. All the complexes were found to be six-coordinate dihydrates. The geometry of the complexes appears to be simple octahedral. All the compounds under investigation possess somewhat antibacterial activity. The antibacterial activity showed the following trend; Transition metal complexes > Schiff base ligand > Parent drug

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