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Preparation, characterization and evaluation of starch phosphate: A new modified starch as directly compressible vehicle in tablet formulations

Author(s): K.P.R. Chowdary* and Veeraiah Enturi

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3241;
Date: 2011;
Original page

Keywords: Starch Phosphate | Directly Compressible Vehicle | Gliclazide | Pioglitazone | Etoricoxib

The objective of the study is to prepare and evaluate starch phosphate, a new chemically modified starch, as a directly compressible vehicle for tablets. Starchphosphate was prepared by reacting starch with di-sodium hydrogen orthophosphate anhydrous at elevated temperatures. Starch phosphate powder of size 152 μm(80/120 mesh) exhibited excellent flow characteristics alone and after mixing drug and other excipients upto 30% and was found suitable for direct compression.Starch phosphate was insoluble in water and aqueous fluids of acidic and alkaline pHs. It also exhibited good swelling (400%) in water. It has no pasting or gellingproperty when heated at 1000C in water for 30 min. Tablets of (i) gliclazide (ii) pioglitazone and (iii) etoricoxib were prepared by direct compression methodemploying starch phosphate (70%) as directly compressible vehicle and the tablets were evaluated. The tablets of gliclazide, pioglitazone and etoricoxib formulatedemploying starch phosphate as directly compressible vehicle gave rapid and higher dissolution of the contained drug apart from fulfilling the official or GMPstandards prescribed for uncoated tablets. A 2.13, 3.45 and 3.96 fold increase in the dissolution rate (K1) was observed respectively with gliclazide, pioglitazone andetoricoxib tablets formulated by direct compression method employing starch phosphate when compared to the corresponding commercial brands. FTIR studyindicated no drug-excipient interaction between starch phosphate and the drugs studied. The starch phosphate, a new modified starch was found to be a promisingdirectly compressible vehicle for the preparation of tablets by direct compression method.
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