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Preparation and evaluation of gels from gum of Moringa oleifera

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Author(s): Panda D | Si S | Swain S | Kanungo S | Gupta R

Journal: Indian Journal of Pharmaceutical Sciences
ISSN 0250-474X

Volume: 68;
Issue: 6;
Start page: 777;
Date: 2006;
Original page

ABSTRACT
The present study was undertaken with an objective to find out the gelling potentials of a natural gum obtained from plant Moringa oleifera . The gum was extracted by using water as solvent and precipitated using acetone as non-solvent. Physical characteristics such as, solubility, swelling index, loss on drying, and pH were studied. Diclofenac sodium was used as model drug for the formulation of gels. Seven batches of drug loaded gels with concentration of mucilage ranging from 5.5, 6.0, 6.5, 7.0, 7.5, 8.0, and 8.5 were formulated by using glycerin as plasticizer and methyl paraben as preservative. The pH, viscosity, and in vitro diffusion profiles were studied. The gels prepared with 8.0% of mucilage were found to be ideal and comparable with a commercial preparation.
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