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Preparation And Evaluation Of Lamivudine Microspheres Using Various Cellulose Polymers

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Author(s): Narasimharao R1*and Prakash.K

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 4;
Start page: 1079;
Date: 2011;
Original page

Keywords: Microspheres | Lamivudine | Cellulose polymers | in-vitro dissolution studies | stability studies

ABSTRACT
The present study was planed to prepare microspheres for sustained release of Lamivudine using various cellulose polymers such as Ethyl cellulose, Cellulose acetate phthalate, cellulose acetateby employing solvent evaporation technique. Microspheres were Characterized for the particle size distribution, wall thickness by scanning electron microscopy (SEM),angle of repose, drugcontent ,bulk density, entrapment efficiency and in vitro dissolution studies. Drug excepients compatibility was determined by FTIR and DTA . Accelerated stability studies were also carriedout following ICH Guidelines .SEM shows that microspheres were found spherical in shape and free flowing. The entrapment efficiency and wall thickness was found in between68.85%&42.88%,120.28μ,&72.32μ respectively. The drug release was extended maximum up to 12 hr with ethyl cellulose .FTIR and DSC results showed Lamivudine was compatible withexcepients .The curve fitting data shows that the drug release followed first order kinetics, higuchi’s and peppa’s plots stated non-fickian diffusion controll
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