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Preparation and evaluation of Metoprolol succinate porous tablets for controlled drug delivery.

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Author(s): Mohammed S. Khan*, Gowda D. Vishakante, Afifa Bathool, Shivakumar H.G

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 8;
Start page: 2657;
Date: 2011;
Original page

Keywords: Metoprolol succinate | ammonium bi carbonate | porous tablets | 3 D bar plots.

ABSTRACT
The present investigation was undertaken to prepare and evaluate porous controlled release tablets of metoprolol succinate using sodium alginate (SA) as a matrixforming agent. Ammonium bi carbonate (AbC) is used as a pore forming agent in the preparations of porous tablets. Pre compression parameters of the powdersblends to make the porous tablets were evaluated for its physico-chemical properties and were found to be within prescribed limits, indicating good free flowingproperty. Tablets were evaluated for physical parameters like hardness, friability, disintegration time, wetting time and in vitro release studies and results were foundto be satisfactory. Influence of pore forming agent on properties of tablets (disintegration, hardness and drug release) were manly investigated. FTIR, DSC wereconducted in order to show drug, polymer excipient compatibility. Ammonium bi carbonate as a pore forming agent proves to be promising and was successful increating pores on surface of tablets. It was found that an increase in pore forming agent leads to decrease in hardness and disintegration time of porous tablets. 3D bar plots were plotted in order to see the effect of pore forming agent on hardness and disintegration time of porous tablets. Drug release was found to be affectedby amount of pore forming agent present in respective batches of tablets. In vitro release data shows that tablets follow zero order release mechanism which wasfurther confirmed by koresmeyer peppas, showing that the value of n is greater than 1 showing case II drug release or anomalous drug release indicating that twoor more mechanism for the drug release are involved, that is diffusion and erosion.
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