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Preparation and Evaluation of Sustained Release Matrix Tablet of Diclofenac Sodium using Natural Polymer

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Author(s): Ganesh G.N.K | Sureshkumar.R | Jawahar.N | Senthil.V | Nagasamy Venkatesh.D | Shanmukha Srinivas.M

Journal: Journal of Pharmaceutical Sciences and Research
ISSN 0975-1459

Volume: 2;
Issue: 6;
Start page: 360;
Date: 2010;
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Keywords: Diclofenac sodium | Cashew nut tree gum | HPMC | Carbopol | Sustained release matrix tablets.

ABSTRACT
Sustained release tablets of Diclofenac Sodium were fabricated using Cashew nut tree gum, HPMC and Carbopol . The tablets were evaluated for preformulation studies like angle of repose, bluk density, compressibility index and physical characteristics like hardness, weight variation, fraibilty and drug content. In-vitro release of drug was performed in PBS pH 7.2 for twelve hours. All the physical characters of the fabricated tablet were within acceptablelimits. The tablet with HPMC(Batch B-I) and Carbopol(Batch C-I) exhibited greater drug content than those with cashew nut tree gum and other batches of HPMC and carbopol. A better sustained drug release (50.65%) was obtained with the matrix tablet (Batch C-III) made-up of the carbopol than with the cashew nut tree gum and HPMC. It is cleared through the dissolution profile of Diclofenac sodium from matrix tablets prepared using different polymers were indicated an increase in the polymer ratio retarded the drug release to a greater extent.

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