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PREPARATION AND IN-VITRO EVALUATION OF BACLOFEN LOADED MICROSPHERES

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Author(s): Polepalle Madhulatha | Valluru Rajashekar | Mandalapu Sravan Kumar | Gaddam Jayanth Kumar Reddy | K.A Sridhar

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 3;
Issue: 9;
Start page: 297;
Date: 2012;
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Keywords: Baclofen | EC | HPMC k100 | microspheres | solvent evaporation method.

ABSTRACT
The present study was aimed to prepare Baclofen microspheres for sustained release using various polymers such as ethyl cellulose (hydrophobic), hydroxy propyl methyl cellulose (hydrophilic) by employing solvent evaporation technique. Drug and excipients compatibility was studied by Fourier Transform Infrared Spectroscopy and no incompatibility was observed. The obtained microspheres were evaluated for the percent drug content, entrapment efficiency and in-vitro dissolution studies. The entrapment efficiency of the obtained formulations was in between 66-88% and in-vitro release of F7 formulation showed 93% in 24 hrs. Scanning Electron Microscopy, Differential Scanning Calorimetry and X-Ray Diffraction studies were performed for F7 formulation. From the results Scanning Electron Microscopy of reveals that microspheres was found in spherical and porous nature. X-Ray Diffraction studies results showed baclofen was in amorphous form which was further confirmed by Differential Scanning Calorimetry. The curve fitting data revealed that the release of obtained formulations follows mixed order kinetics with nonā€fickian type of drug release (anomalous).
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