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Preparation of mucoadhesive microspheres for nasal delivery by spray drying

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Author(s): Rathananand Mahalaxmi | Kumar D | Shirwaikar A | Kumar Ravi | Sampath Kumar D | Prasad R

Journal: Indian Journal of Pharmaceutical Sciences
ISSN 0250-474X

Volume: 69;
Issue: 5;
Start page: 651;
Date: 2007;
Original page

Keywords: Microspheres | nasal delivery | spray drying | levocetirizine

ABSTRACT
In this study the suitability of spray drying as a method for the formulation of mucoadhesive microspheres for nasal delivery was evaluated. The microspheres were produced from mucoadhesive polymers including chitosan salt, hydroxypropylmethylcellulose, hydroxypropylcellulose, sodium alginate and contained levocetirizine dihydrochloride as the model drug. The microspheres formed were evaluated for particle size distribution, drug loading, production yield, in vitro release characteristics and suitability for nasal drug delivery in terms of particle size and release properties. The conditions of the spray dryer were optimized for production yield and particle size.
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